JAK1

Across TCGA cell cohorts, JAK1 mutation is significantly associated with the RNA expression of many other genes, with 211 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible JAK1-associated genes across cancer lineages are OR9A2, BTNL2, and RTL4. Each is linked with JAK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both JAK1-to-partner and partner-to-JAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9A2 grouped by JAK1-low versus JAK1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAK1→partner) and Y-score (partner→JAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR9A2 →	+0.022	+5.209	<.001	.005	3	3
CNS	BTNL2 →	+0.031	+4.169	.001	.008	3	3
BLOOD_Myeloma	RTL4 →	+0.023	+4.807	<.001	.006	3	2
BLOOD_Leukemia	OR11H6 →	+0.028	+3.705	<.001	.007	3	2
BLOOD_Leukemia	GFRAL →	+0.020	+4.984	<.001	.002	3	2
UPPER_AERODIGESTIVE_TRACT	OR4F15 →	+0.043	+4.736	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 211 associations by consensus.

OR9A2 by JAK1 expression — BLOOD_Lymphoma

Explore this box plot interactively →