Across TCGA patient cohorts, JAG2 protein abundance is significantly associated with the RNA expression of many other genes, with 2,352 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible JAG2-associated genes across cancer lineages are CRHR2, ST3GAL3, and PGPEP1. Each is linked with JAG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both JAG2-to-partner and partner-to-JAG2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAG2→partner) and Y-score (partner→JAG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CRHR2 →	-0.838	-0.504	.006	.006	3	2
HNSC	ST3GAL3 →	-0.688	-0.538	.001	.003	3	2
GBM	PGPEP1 →	-0.719	-0.801	.002	.003	3	2
HNSC	LY6K →	+1.226	+0.722	<.001	<.001	3	2
LSCC	MMP10 →	+2.219	+0.659	.001	.001	3	2
HNSC	CIB1 →	+1.108	+0.490	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,352 associations by consensus.

Exploration

JAG2 survival (RNA) · tumor vs normal (RNA) · all JAG2 data types