Across TCGA pan-cancer cohorts, JAG2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of JAG2’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where JAG2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types JAG2 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.
KIRC, COAD, and HNSC are the cancer types where JAG2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in JAG2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.