Across TCGA patient cohorts, JAG2 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JAG2-associated genes across cancer lineages are Caspase-7-cleavedD198, ERK2, and JNK2. Each is linked with JAG2 in more than 2 cancer types. Because this analysis shows association rather than direction, both JAG2-to-partner and partner-to-JAG2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAG2→partner) and Y-score (partner→JAG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.752	+3.459	<.001	.005	3	3
UCEC	ERK2 →	+0.144	+2.222	.042	.010	3	2
UCEC	JNK2 →	+0.296	+2.594	<.001	.006	3	2
UCEC	AMPK_pT172 →	+0.373	+1.861	.013	.005	3	2
UCEC	Cyclin-B1 →	+0.479	+2.321	.020	.033	3	2
STAD	Cyclin-E2 →	+0.183	+2.828	.013	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

JAG2 survival (RNA) · tumor vs normal (RNA) · all JAG2 data types