JAG1

Across TCGA patient cohorts, JAG1 mutation is significantly associated with the RNA expression of many other genes, with 3,966 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JAG1-associated genes across cancer lineages are OR5AN1, ADAMTSL2, and MIR6856. Each is linked with JAG1 in more than 4 cancer types. Because this analysis shows association rather than direction, both JAG1-to-partner and partner-to-JAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5AN1 grouped by JAG1-low versus JAG1-high in OV.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAG1→partner) and Y-score (partner→JAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	OR5AN1 →	+0.092	+5.297	<.001	.006	3	5
COAD	ADAMTSL2 →	-0.649	-3.584	.002	.002	3	4
GBM	MIR6856 →	+0.643	+5.149	<.001	.007	3	3
LUAD	TFAMP1 →	+0.362	+3.668	<.001	.003	3	3
SARC	SEPTIN14P17 →	+0.190	+4.620	.004	.007	3	3
STAD	ADAMTS8 →	-1.029	-3.459	.009	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,966 associations by consensus.

OR5AN1 by JAG1 expression — OV

Explore this box plot interactively →