JADE1

Across TCGA pan-cancer cohorts, JADE1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated JADE1 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher JADE1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated JADE1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

CCRCC, LSCC, and HNSC are the cancer types where JADE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.802	1.000	.008	17	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.393	.005	7	view →
HNSC	OS	Median	II,III,IV	0.889	0.610	.039	4	view →
LUAD	OS	Tertile	II,III,IV	0.846	0.493	.031	3	view →
GBM	OS	Quartile	All	0.966	0.656	.012	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

JADE1–CCRCC (DFS)

Open the CCRCC breakdown →