JADE1

Across TCGA pan-cancer cohorts, JADE1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of JADE1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where JADE1 RNA is repressed in tumor relative to normal tissue. In most cancer types JADE1 is over-expressed in tumor, although a few such as BLCA and LUSC show the opposite, repressed pattern.

BLCA, LUSC, and KIRC are the cancer types where JADE1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in JADE1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	−0.958	.001	10	view →
LUSC	Male	All	−1.336	<.001	9	view →
KIRC	All	III,IV	−0.483	<.001	9	view →
LIHC	Female	II,III,IV	+0.834	<.001	7	view →
HNSC	All	All	−0.441	.001	7	view →
LUAD	Female	II,III,IV	−1.235	<.001	6	view →
BRCA	Female	All	−0.976	<.001	6	view →
KIRP	All	All	−0.642	<.001	6	view →
THCA	All	All	−0.429	<.001	6	view →
CHOL	All	All	+1.665	<.001	5	view →
UCEC	All	All	−0.641	.001	2	view →
COAD	All	All	+0.230	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

JADE1–BLCA

Open the BLCA breakdown →