JADE1

Across TCGA patient cohorts, JADE1 mutation is significantly associated with the RNA expression of many other genes, with 6,911 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JADE1-associated genes across cancer lineages are PFKFB4, MFN2, and VPS4B. Each is linked with JADE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both JADE1-to-partner and partner-to-JADE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PFKFB4 grouped by JADE1-low versus JADE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JADE1→partner) and Y-score (partner→JADE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PFKFB4 →	+0.949	+2.332	<.001	<.001	3	3
UCEC	MFN2 →	+0.556	+2.664	<.001	<.001	3	3
UCEC	VPS4B →	+0.512	+2.662	<.001	<.001	3	3
UCEC	MED18 →	+0.519	+1.828	<.001	<.001	3	3
UCEC	TOE1 →	+0.366	+2.343	<.001	.003	3	3
UCEC	IER3IP1 →	+0.460	+1.860	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,911 associations by consensus.

PFKFB4 by JADE1 expression — UCEC

Explore this box plot interactively →