IZUMO2

Across TCGA cell cohorts, IZUMO2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible IZUMO2-associated genes across cancer lineages are OR52N5, PRR23B, and C1orf185. Each is linked with IZUMO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IZUMO2-to-partner and partner-to-IZUMO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52N5 grouped by IZUMO2-low versus IZUMO2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IZUMO2→partner) and Y-score (partner→IZUMO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR52N5 →	+0.130	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRR23B →	+0.006	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	C1orf185 →	+0.053	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR52E6 →	+0.206	+4.887	<.001	.009	3	1
LARGE_INTESTINE	CCL18 →	+0.097	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR52N5 by IZUMO2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →