IZUMO1

Across TCGA patient cohorts, IZUMO1 mutation is significantly associated with the RNA expression of many other genes, with 3,711 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IZUMO1-associated genes across cancer lineages are MIR128-1, MYOM3-AS1, and IGHD6-19. Each is linked with IZUMO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IZUMO1-to-partner and partner-to-IZUMO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR128-1 grouped by IZUMO1-low versus IZUMO1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IZUMO1→partner) and Y-score (partner→IZUMO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR128-1 →	+0.234	+4.038	<.001	.002	3	2
LUSC	MYOM3-AS1 →	+0.130	+5.337	<.001	.006	3	2
UCEC	IGHD6-19 →	+0.556	+2.420	<.001	.009	3	2
UCEC	MTATP6P21 →	+0.202	+2.074	.001	.004	3	2
CESC	CYTH1P1 →	+0.071	+4.193	.006	.009	3	2
HNSC	RNU6-1082P →	+0.521	+5.124	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,711 associations by consensus.

MIR128-1 by IZUMO1 expression — BLCA

Explore this box plot interactively →