IZUMO1

Across TCGA pan-cancer cohorts, IZUMO1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IZUMO1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IZUMO1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IZUMO1 is over-expressed in tumor, although a few such as LUAD and KIRP show the opposite, repressed pattern.

COAD, LIHC, and HNSC are the cancer types where IZUMO1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IZUMO1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+0.192	<.001	10	view →
LIHC	All	II,III,IV	+0.130	<.001	8	view →
HNSC	All	All	+0.182	.007	7	view →
LUAD	All	All	−0.327	<.001	6	view →
CHOL	All	All	+0.297	.005	4	view →
KIRP	Male	All	−0.170	<.001	4	view →
BRCA	All	III,IV	−0.107	.007	4	view →
ESCA	All	All	−0.510	.012	2	view →
READ	All	All	+0.193	.049	1	view →
THCA	All	All	+0.060	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IZUMO1–COAD

Open the COAD breakdown →