IYD

Across TCGA pan-cancer cohorts, IYD mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IYD data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IYD mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IYD expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

LUAD, CCRCC, and COAD are the cancer types where IYD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.145	0.888	.001	28	view →
CCRCC	OS	Tertile	All	1.000	0.907	.016	20	view →
COAD	DFS	Median	All	1.000	0.929	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

IYD–LUAD (DFS)

Open the LUAD breakdown →