IYD

Across TCGA pan-cancer cohorts, IYD RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of IYD’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IYD RNA is repressed in tumor relative to normal tissue. In most cancer types IYD is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KIRP are the cancer types where IYD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IYD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−2.123	<.001	12	view →
THCA	Male	III,IV	−4.160	<.001	11	view →
KIRP	Female	II,III,IV	−3.374	<.001	9	view →
LIHC	Male	II,III,IV	−1.652	<.001	8	view →
KICH	Female	II,III,IV	−2.421	<.001	7	view →
LUSC	Female	II,III,IV	−1.124	<.001	7	view →
BRCA	All	All	+0.338	.003	6	view →
CHOL	All	All	−2.021	<.001	4	view →
STAD	All	All	+1.230	.002	4	view →
BLCA	All	All	+0.402	.022	4	view →
HNSC	All	All	−0.150	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

IYD–KIRC

Open the KIRC breakdown →