IYD

Across TCGA patient cohorts, IYD mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IYD-associated genes across cancer lineages are Ku80, VHL, and Akt_pS473. Each is linked with IYD in more than 1 cancer types. Because this analysis shows association rather than direction, both IYD-to-partner and partner-to-IYD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by IYD-low versus IYD-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IYD→partner) and Y-score (partner→IYD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Ku80 →	+0.308	+3.459	.025	.005	3	2
UCEC	VHL →	-0.916	-2.700	.002	.006	3	2
SKCM	Akt_pS473 →	-0.694	-3.000	.010	.035	3	1
SKCM	c-Myc →	+0.275	+2.321	.047	.035	3	1
UCEC	FoxM1 →	+0.262	+2.331	.024	.019	3	1
UCEC	Notch1 →	+0.200	+2.000	.001	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Ku80 by IYD expression — SKCM

Explore this box plot interactively →