IYD

Across TCGA cell cohorts, IYD RNA expression is significantly associated with the go_rna of many other GO terms, with 2,305 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IYD-associated GO terms across cancer lineages are Activation of GTPase activity, Positive regulation of endoplasmic reticulum unfolded protein response, and Negative regulation of potassium ion transmembrane transporter activity. Each is linked with IYD in more than 7 cancer types. Because this analysis shows association rather than direction, both IYD-to-partner and partner-to-IYD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Activation of GTPase activity grouped by IYD-low versus IYD-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IYD→partner) and Y-score (partner→IYD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Activation of GTPase activity →	+0.061	+0.721	.003	.001	3	8
LUNG_NSCLC_LUAD	Positive regulation of endoplasmic reticulum unfolded protein response →	+0.049	+0.369	.005	.008	2	8
STOMACH	Negative regulation of potassium ion transmembrane transporter activity →	+1.572	+1.590	<.001	<.001	3	6
STOMACH	Negative regulation of delayed rectifier potassium channel activity →	+1.564	+1.580	<.001	<.001	3	6
STOMACH	Negative regulation of voltage-gated potassium channel activity →	+1.572	+1.590	<.001	<.001	3	6
STOMACH	Secretion by tissue →	+0.257	+1.285	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,305 associations by consensus.

Activation of GTPase activity by IYD expression — BREAST

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