IWS1

Across TCGA patient cohorts, IWS1 protein abundance is significantly associated with the protein abundance of many other proteins, with 26,411 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IWS1-associated proteins across cancer lineages are BCLAF1, CPSF6, and DDX23. Each is linked with IWS1 in more than 9 cancer types. Because this analysis shows association rather than direction, both IWS1-to-partner and partner-to-IWS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IWS1 versus BCLAF1 in GBM, with a Pearson correlation of 0.73.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IWS1→partner) and Y-score (partner→IWS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BCLAF1 →	+0.386	+0.414	<.001	<.001	3	10
OV	CPSF6 →	+0.393	+0.447	<.001	<.001	3	10
LSCC	DDX23 →	+0.349	+0.322	<.001	<.001	3	10
GBM	HNRNPR →	+0.464	+0.439	<.001	<.001	3	10
GBM	SNRPD2 →	+0.366	+0.420	<.001	<.001	3	10
GBM	SRRT →	+0.394	+0.445	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 26,411 associations by consensus.

IWS1 vs BCLAF1 — GBM

Explore this scatter interactively →