IVNS1ABP

Across TCGA patient cohorts, IVNS1ABP mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IVNS1ABP-associated genes across cancer lineages are mTOR_pS2448, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with IVNS1ABP in more than 1 cancer types. Because this analysis shows association rather than direction, both IVNS1ABP-to-partner and partner-to-IVNS1ABP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by IVNS1ABP-low versus IVNS1ABP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IVNS1ABP→partner) and Y-score (partner→IVNS1ABP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.124	-1.986	.011	.008	3	2
UCEC	Caspase-7-cleavedD198 →	+0.455	+1.697	.020	.012	3	2
UCEC	4E-BP1 →	+0.296	+3.700	<.001	.001	3	2
UCEC	C-Raf →	+0.140	+1.392	.002	.019	3	2
UCEC	14-3-3_beta →	-0.096	-2.780	.003	.003	3	1
UCEC	EGFR_pY1068 →	-0.247	-1.938	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

mTOR_pS2448 by IVNS1ABP expression — UCEC

Explore this box plot interactively →