IVNS1ABP

Across TCGA pan-cancer cohorts, IVNS1ABP RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated IVNS1ABP data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher IVNS1ABP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IVNS1ABP expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

KIRP, ACC, and KIRC are the cancer types where IVNS1ABP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.510	0.835	<.001	132	view →
ACC	OS	Median	All	0.774	0.962	<.001	102	view →
KIRC	OS	Median	All	0.743	0.525	<.001	102	view →
MESO	OS	Median	All	0.248	0.511	<.001	57	view →
LIHC	OS	Quartile	All	0.664	0.856	.001	51	view →
SARC	OS	Median	All	0.667	0.815	.001	31	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
UVM	DFS	Median	III,IV	0.264	0.631	.003	20	view →
BRCA	OS	Tertile	All	0.896	0.941	.004	18	view →
ESCA	OS	Median	IV	0.222	0.698	.006	15	view →
SCLC	OS	Median	IV	0.219	0.729	.003	15	view →
CESC	DFS	Quartile	III,IV	0.586	0.893	.022	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

IVNS1ABP–KIRP (DFS)

Open the KIRP breakdown →