IVL

Across TCGA patient cohorts, IVL protein abundance is significantly associated with the RNA expression of many other genes, with 11,244 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IVL-associated genes across cancer lineages are SPRR1B, TMEM40, and GRHL1. Each is linked with IVL in more than 5 cancer types. Because this analysis shows association rather than direction, both IVL-to-partner and partner-to-IVL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IVL versus SPRR1B in LSCC, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IVL→partner) and Y-score (partner→IVL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPRR1B →	+3.052	+1.414	<.001	<.001	3	6
BRCA	TMEM40 →	+1.620	+1.396	<.001	<.001	3	6
LSCC	GRHL1 →	+0.995	+1.355	<.001	<.001	3	5
LSCC	NECTIN4 →	+0.778	+0.973	<.001	<.001	3	5
HNSC	MPZL3 →	+0.643	+1.056	<.001	<.001	3	5
UCEC	CST6 →	+1.805	+1.589	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,244 associations by consensus.

IVL vs SPRR1B — LSCC

Explore this scatter interactively →