IVL

Across TCGA cell cohorts, IVL mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IVL-associated genes across cancer lineages are NXPH2, PDHA2, and OR8B12. Each is linked with IVL in more than 1 cancer types. Because this analysis shows association rather than direction, both IVL-to-partner and partner-to-IVL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NXPH2 grouped by IVL-low versus IVL-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IVL→partner) and Y-score (partner→IVL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NXPH2 →	+0.022	+4.017	<.001	.007	3	1
LUNG_SCLC	PDHA2 →	+0.026	+5.029	<.001	.006	3	1
LUNG_SCLC	OR8B12 →	+0.021	+5.029	.001	.006	3	1
BLOOD_Lymphoma	BANF2 →	+0.057	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	HS3ST4 →	+0.044	+3.736	<.001	.009	3	1
BLOOD_Lymphoma	SERPINB11 →	+0.095	+4.459	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

NXPH2 by IVL expression — OESOPHAGUS

Explore this box plot interactively →