IVD

Across TCGA patient cohorts, IVD RNA expression is significantly associated with the protein abundance of many other proteins, with 15,137 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IVD-associated proteins across cancer lineages are DDAH1, USP8, and DNAJC17. Each is linked with IVD in more than 6 cancer types. Because this analysis shows association rather than direction, both IVD-to-partner and partner-to-IVD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IVD versus DDAH1 in BRCA, with a Pearson correlation of 0.56.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IVD→partner) and Y-score (partner→IVD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDAH1 →	+0.656	+0.889	<.001	<.001	3	7
GBM	USP8 →	+0.297	+0.537	<.001	<.001	3	6
GBM	DNAJC17 →	+0.261	+0.301	.004	.009	2	7
BRCA	TP53BP1 →	+0.374	+0.851	<.001	<.001	3	6
COAD	RPUSD2 →	+0.566	+0.626	<.001	.003	3	5
OV	SRP14 →	+0.416	+0.567	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,137 associations by consensus.

IVD vs DDAH1 — BRCA

Explore this scatter interactively →