IVD

Across TCGA pan-cancer cohorts, IVD RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IVD data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher IVD RNA is associated with better overall survival. In most high-consensus cancer types, elevated IVD expression acts as an unfavorable survival marker, although some lineages such as MESO and KIRC show a favorable association.

MESO, KIRC, and KIRP are the cancer types where IVD RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.484	0.287	.001	75	view →
KIRC	DFS	Median	All	0.726	0.534	<.001	60	view →
KIRP	OS	Quartile	All	0.977	0.803	<.001	50	view →
LIHC	OS	Median	All	0.765	0.606	<.001	34	view →
LUAD	OS	Tertile	All	0.770	0.633	.003	20	view →
BRCA	OS	Quartile	III,IV	0.861	0.682	.013	19	view →
HNSC	OS	Tertile	All	0.635	0.831	.002	16	view →
COAD	DFS	Median	IV	0.282	0.659	.005	15	view →
ACC	OS	Quartile	III,IV	0.694	0.190	.009	13	view →
OV	OS	Tertile	II,III,IV	0.302	0.409	.020	12	view →
UVM	DFS	Median	All	0.271	0.617	.018	12	view →
DLBC	DFS	Tertile	II,III,IV	0.216	0.916	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IVD–MESO (OS)

Open the MESO breakdown →