IVD

Across TCGA patient cohorts, IVD protein abundance is significantly associated with the RNA expression of many other genes, with 14,052 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IVD-associated genes across cancer lineages are PLLP, MCM5, and MCM4. Each is linked with IVD in more than 5 cancer types. Because this analysis shows association rather than direction, both IVD-to-partner and partner-to-IVD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IVD versus PLLP in LUAD, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IVD→partner) and Y-score (partner→IVD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLLP →	+0.809	+0.303	<.001	<.001	3	6
OV	MCM5 →	-0.781	-0.576	<.001	<.001	3	5
OV	MCM4 →	-0.757	-0.531	<.001	<.001	3	5
LUAD	CENPF →	-1.014	-0.318	<.001	<.001	3	5
BRCA	KIF14 →	-1.033	-0.560	<.001	<.001	3	5
BRCA	KIF18A →	-0.773	-0.508	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,052 associations by consensus.

IVD vs PLLP — LUAD

Explore this scatter interactively →