IVD

Across TCGA patient cohorts, IVD mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IVD-associated genes across cancer lineages are JNK2, Rab25, and EGFR_pY1068. Each is linked with IVD in more than 1 cancer types. Because this analysis shows association rather than direction, both IVD-to-partner and partner-to-IVD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by IVD-low versus IVD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IVD→partner) and Y-score (partner→IVD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.227	+1.807	.005	.027	3	2
UCEC	Rab25 →	-0.295	-1.807	.031	.027	3	2
UCEC	EGFR_pY1068 →	-0.298	-2.459	.004	.019	3	1
UCEC	EGFR →	-0.214	-1.807	.001	.027	3	1
UCEC	eIF4E →	+0.187	+2.321	.032	.006	3	1
UCEC	FoxM1 →	+0.219	+1.807	.040	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

JNK2 by IVD expression — UCEC

Explore this box plot interactively →