IVD

Across TCGA cell cohorts, IVD RNA expression is significantly associated with the go_rna of many other GO terms, with 3,353 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IVD-associated GO terms across cancer lineages are Regulation of DNA repair, Transcription elongation by RNA polymerase II, and Microtubule nucleation. Each is linked with IVD in more than 12 cancer types. Because this analysis shows association rather than direction, both IVD-to-partner and partner-to-IVD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA repair grouped by IVD-low versus IVD-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IVD→partner) and Y-score (partner→IVD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of DNA repair →	+0.055	+0.944	<.001	.008	3	12
SOFT_TISSUE	Transcription elongation by RNA polymerase II →	+0.072	+0.784	<.001	.004	3	12
BONE	Microtubule nucleation →	+0.134	+0.736	.001	.002	2	13
OESOPHAGUS	Metaphase/anaphase transition of cell cycle →	+0.136	+1.418	<.001	.002	2	12
OESOPHAGUS	Metaphase/anaphase transition of mitotic cell cycle →	+0.137	+1.400	<.001	.002	2	12
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA-templated transcription initiation →	+0.058	+1.825	.002	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,353 associations by consensus.

Regulation of DNA repair by IVD expression — LARGE_INTESTINE

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