Across TCGA cell cohorts, ITSN1 mutation is significantly associated with the mutation status of many other genes, with 6,112 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITSN1-associated genes across cancer lineages are WDFY3, TEX2, and SORBS2. Each is linked with ITSN1 in more than 5 cancer types. Because this analysis shows association rather than direction, both ITSN1-to-partner and partner-to-ITSN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITSN1→partner) and Y-score (partner→ITSN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	WDFY3 →	+1.932	+2.325	.005	.005	1	6
BLOOD_Lymphoma	TEX2 →	+4.659	+4.053	<.001	<.001	1	6
OESOPHAGUS	SORBS2 →	+3.672	+4.307	.004	.004	1	5
BLOOD_Leukemia	PLXNA4 →	+3.083	+3.545	<.001	<.001	1	5
LARGE_INTESTINE	SYNPO2 →	+2.925	+2.514	<.001	<.001	1	5
LARGE_INTESTINE	TBC1D10C →	+4.247	+2.459	.001	.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,112 associations by consensus.

Exploration

ITSN1 survival (RNA) · tumor vs normal (RNA) · all ITSN1 data types