ITPRIP

Across TCGA patient cohorts, ITPRIP mutation is significantly associated with the RNA expression of many other genes, with 3,297 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITPRIP-associated genes across cancer lineages are PSMC3IP, CKAP2L, and UTP11. Each is linked with ITPRIP in more than 3 cancer types. Because this analysis shows association rather than direction, both ITPRIP-to-partner and partner-to-ITPRIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMC3IP grouped by ITPRIP-low versus ITPRIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPRIP→partner) and Y-score (partner→ITPRIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMC3IP →	+0.595	+3.111	<.001	<.001	3	4
UCEC	CKAP2L →	+0.708	+2.906	<.001	.001	3	4
UCEC	UTP11 →	+0.427	+1.790	.002	.004	3	3
UCEC	CDCA2 →	+0.870	+3.016	<.001	<.001	2	4
UCEC	CENPP →	+0.246	+2.906	.001	.001	3	3
SKCM	CENPA →	+0.678	+1.925	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,297 associations by consensus.

PSMC3IP by ITPRIP expression — UCEC

Explore this box plot interactively →