ITPRIP

Across TCGA pan-cancer cohorts, ITPRIP RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ITPRIP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ITPRIP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ITPRIP is over-expressed in tumor, although a few such as LUAD and UCEC show the opposite, repressed pattern.

KIRC, LUAD, and COAD are the cancer types where ITPRIP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITPRIP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.296	<.001	11	view →
LUAD	Female	All	−1.340	<.001	10	view →
COAD	Male	II,III,IV	+0.750	<.001	9	view →
UCEC	All	All	−1.129	<.001	6	view →
BRCA	All	All	−0.374	<.001	6	view →
BLCA	All	All	−0.998	<.001	5	view →
LUSC	All	II,III,IV	−0.859	<.001	5	view →
KICH	All	All	−0.818	<.001	4	view →
HNSC	All	All	+0.419	.016	3	view →
PRAD	All	All	−0.430	.002	2	view →
READ	All	All	+0.836	.027	1	view →
KIRP	Male	All	−0.484	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ITPRIP–KIRC

Open the KIRC breakdown →