ITPRIP

Across TCGA patient cohorts, ITPRIP mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITPRIP-associated genes across cancer lineages are PDCD4, ATM, and 4E-BP1. Each is linked with ITPRIP in more than 1 cancer types. Because this analysis shows association rather than direction, both ITPRIP-to-partner and partner-to-ITPRIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by ITPRIP-low versus ITPRIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPRIP→partner) and Y-score (partner→ITPRIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.590	-2.584	<.001	.010	3	2
UCEC	ATM →	-0.519	-2.807	.002	.003	3	2
UCEC	4E-BP1 →	+0.349	+3.837	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.079	-2.295	.035	.033	3	1
UCEC	eEF2 →	+0.284	+1.415	.034	.046	3	1
UCEC	EGFR_pY1068 →	-0.232	-1.415	.013	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

PDCD4 by ITPRIP expression — UCEC

Explore this box plot interactively →