ITPRIP

Across TCGA cell cohorts, ITPRIP mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ITPRIP-associated genes across cancer lineages are SIGLEC8, CSTL1, and PLCZ1. Each is linked with ITPRIP in more than 1 cancer types. Because this analysis shows association rather than direction, both ITPRIP-to-partner and partner-to-ITPRIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC8 grouped by ITPRIP-low versus ITPRIP-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPRIP→partner) and Y-score (partner→ITPRIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SIGLEC8 →	+0.015	+4.714	.006	.002	3	1
BLOOD_Lymphoma	CSTL1 →	+0.428	+5.452	<.001	<.001	3	1
BLOOD_Lymphoma	PLCZ1 →	+0.127	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	RPL10L →	+0.191	+4.191	<.001	.007	3	1
BLOOD_Lymphoma	XAGE5 →	+0.534	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	NEUROG1 →	+0.004	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

SIGLEC8 by ITPRIP expression — BLOOD_Lymphoma

Explore this box plot interactively →