ITPRID2

Across TCGA patient cohorts, ITPRID2 mutation is significantly associated with the RNA expression of many other genes, with 5,462 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITPRID2-associated genes across cancer lineages are SPC25, NF2, and SF3A1. Each is linked with ITPRID2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ITPRID2-to-partner and partner-to-ITPRID2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPC25 grouped by ITPRID2-low versus ITPRID2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPRID2→partner) and Y-score (partner→ITPRID2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPC25 →	+0.527	+1.839	.001	<.001	3	5
UCEC	NF2 →	+0.451	+1.638	<.001	<.001	3	4
SKCM	SF3A1 →	+0.459	+3.347	.004	.004	3	4
UCEC	CHAF1B →	+0.656	+1.628	<.001	<.001	3	4
UCEC	SPC24 →	+0.517	+1.628	.001	<.001	3	4
UCEC	RRM2 →	+0.975	+2.440	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,462 associations by consensus.

SPC25 by ITPRID2 expression — UCEC

Explore this box plot interactively →