ITPRID2

Across TCGA pan-cancer cohorts, ITPRID2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ITPRID2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ITPRID2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ITPRID2 is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

HNSC, LUAD, and COAD are the cancer types where ITPRID2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITPRID2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.736	<.001	12	view →
LUAD	Female	III,IV	−1.683	<.001	11	view →
COAD	All	All	−0.500	<.001	8	view →
THCA	All	All	−0.474	<.001	8	view →
KICH	Female	All	−1.732	<.001	7	view →
KIRC	Male	III,IV	−0.488	.003	7	view →
STAD	Male	II,III,IV	+1.067	<.001	6	view →
CHOL	Male	All	+0.881	.001	4	view →
READ	All	All	−0.970	<.001	3	view →
LUSC	All	All	−0.418	.005	3	view →
PAAD	All	All	+0.857	.006	2	view →
PRAD	All	All	−0.283	.047	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ITPRID2–HNSC

Open the HNSC breakdown →