ITPR3

Across TCGA cell cohorts, ITPR3 mutation is significantly associated with the RNA expression of many other genes, with 1,529 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITPR3-associated genes across cancer lineages are DCAF12L1, ASPHD2, and ERI3. Each is linked with ITPR3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ITPR3-to-partner and partner-to-ITPR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCAF12L1 grouped by ITPR3-low versus ITPR3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPR3→partner) and Y-score (partner→ITPR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DCAF12L1 →	+0.312	+2.879	<.001	.003	3	4
LARGE_INTESTINE	ASPHD2 →	+0.766	+2.458	<.001	<.001	3	3
LARGE_INTESTINE	ERI3 →	+0.347	+3.169	.005	.006	3	3
LARGE_INTESTINE	EXOSC9 →	+0.647	+3.321	<.001	.002	3	3
LARGE_INTESTINE	SEPTIN11 →	+0.672	+1.949	.005	.002	3	3
LARGE_INTESTINE	SEC24B →	+0.585	+2.458	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,529 associations by consensus.

DCAF12L1 by ITPR3 expression — SOFT_TISSUE

Explore this box plot interactively →