ITPR3

Across TCGA cell cohorts, ITPR3 mutation is significantly associated with the mutation status of many other genes, with 6,746 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITPR3-associated genes across cancer lineages are SPEG, SBF1, and CENPF. Each is linked with ITPR3 in more than 6 cancer types. Because this analysis shows association rather than direction, both ITPR3-to-partner and partner-to-ITPR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPEG grouped by ITPR3-low versus ITPR3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPR3→partner) and Y-score (partner→ITPR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SPEG →	+2.421	+3.376	.002	.002	1	7
LARGE_INTESTINE	SBF1 →	+2.091	+2.190	<.001	<.001	1	7
URINARY_TRACT	CENPF →	+3.672	+4.307	.004	.004	1	6
OVARY	PCSK5 →	+5.099	+4.047	<.001	<.001	1	6
LARGE_INTESTINE	LRP1 →	+1.972	+3.148	<.001	<.001	1	6
LUNG_SCLC	POLR3A →	+5.022	+4.066	.001	.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,746 associations by consensus.

SPEG by ITPR3 expression — OVARY

Explore this box plot interactively →