ITPR1

Across TCGA patient cohorts, ITPR1 protein abundance is significantly associated with the RNA expression of many other genes, with 18,350 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ITPR1-associated genes across cancer lineages are MAN1C1, GYPC, and FLI1. Each is linked with ITPR1 in more than 6 cancer types. Because this analysis shows association rather than direction, both ITPR1-to-partner and partner-to-ITPR1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITPR1 versus MAN1C1 in HNSC, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPR1→partner) and Y-score (partner→ITPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MAN1C1 →	+0.744	+0.241	<.001	<.001	3	7
OV	GYPC →	+1.024	+0.424	.001	.001	3	7
LSCC	FLI1 →	+0.853	+0.423	<.001	<.001	3	7
HNSC	CCDC69 →	+1.251	+0.413	<.001	<.001	3	7
LSCC	GIMAP1 →	+0.673	+0.410	<.001	<.001	3	7
UCEC	CHRDL1 →	+2.031	+0.477	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,350 associations by consensus.

ITPR1 vs MAN1C1 — HNSC

Explore this scatter interactively →