ITPR1

Across TCGA cell cohorts, ITPR1 mutation is significantly associated with the RNA expression of many other genes, with 889 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITPR1-associated genes across cancer lineages are ZNF410, HTD2, and OR2AE1. Each is linked with ITPR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITPR1-to-partner and partner-to-ITPR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF410 grouped by ITPR1-low versus ITPR1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPR1→partner) and Y-score (partner→ITPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF410 →	+0.316	+1.850	.007	.006	3	3
LARGE_INTESTINE	HTD2 →	+0.494	+2.584	<.001	.002	3	3
SOFT_TISSUE	OR2AE1 →	+0.038	+3.095	.004	.009	3	2
OESOPHAGUS	MAGEB4 →	+0.082	+3.392	.007	.007	3	2
BLOOD_Lymphoma	OR1Q1 →	+0.110	+3.276	<.001	.003	3	2
BLOOD_Lymphoma	C1orf146 →	+0.047	+2.874	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 889 associations by consensus.

ZNF410 by ITPR1 expression — LARGE_INTESTINE

Explore this box plot interactively →