ITPKB

Across TCGA pan-cancer cohorts, ITPKB Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ITPKB data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ITPKB Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITPKB expression acts as an unfavorable survival marker.

HNSC, OV, and LIHC are the cancer types where ITPKB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.154	0.712	<.001	33	view →
OV	DFS	Median	All	0.246	0.542	.028	24	view →
LIHC	DFS	Median	All	0.047	0.558	<.001	18	view →
LGG	DFS	Median	All	0.185	0.728	.006	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ITPKB–HNSC (DFS)

Open the HNSC breakdown →