ITPKB

Across TCGA pan-cancer cohorts, ITPKB RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ITPKB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ITPKB RNA is repressed in tumor relative to normal tissue. In most cancer types ITPKB is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and HNSC are the cancer types where ITPKB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITPKB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−2.317	<.001	11	view →
KIRC	Male	II,III,IV	−1.092	<.001	11	view →
HNSC	All	III,IV	+0.858	<.001	11	view →
KIRP	Male	All	−1.685	<.001	9	view →
LUAD	Female	II,III,IV	−0.946	<.001	9	view →
BLCA	Male	IV	−3.035	<.001	8	view →
UCEC	All	All	−1.390	<.001	6	view →
BRCA	Female	All	−0.423	<.001	6	view →
LIHC	Female	II,III,IV	+1.073	<.001	5	view →
COAD	All	All	−0.413	.008	4	view →
READ	Female	All	−1.560	.019	2	view →
CHOL	All	All	+1.400	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ITPKB–KICH

Open the KICH breakdown →