ITPKB

Across TCGA pan-cancer cohorts, ITPKB mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ITPKB data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ITPKB mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ITPKB expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where ITPKB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.940	0.744	<.001	67	view →
LUAD	OS	Tertile	II,III,IV	0.827	0.371	.003	17	view →
PDAC	DFS	Median	II,III,IV	0.340	0.195	.019	7	view →
HNSC	OS	Median	All	1.000	0.958	.020	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ITPKB–CCRCC (OS)

Open the CCRCC breakdown →