ITPKB

Across TCGA patient cohorts, ITPKB mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITPKB-associated genes across cancer lineages are ACC1, p90 RSK, and ASNS. Each is linked with ITPKB in more than 2 cancer types. Because this analysis shows association rather than direction, both ITPKB-to-partner and partner-to-ITPKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by ITPKB-low versus ITPKB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPKB→partner) and Y-score (partner→ITPKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.268	+1.432	.012	.005	3	3
SKCM	p90 RSK →	+0.235	+2.321	.025	.035	3	3
UCEC	ASNS →	+0.349	+1.678	.001	.019	3	3
UCEC	14-3-3_beta →	-0.071	-1.420	.015	.022	3	2
UCEC	FASN →	+0.274	+1.440	.018	.022	3	2
UCEC	Notch1 →	+0.115	+1.515	.005	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ACC1 by ITPKB expression — UCEC

Explore this box plot interactively →