ITPKB

Across TCGA cell cohorts, ITPKB RNA expression is significantly associated with the go_rna of many other GO terms, with 5,095 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ITPKB-associated GO terms across cancer lineages are DNA integrity checkpoint signaling, Regulation of double-strand break repair, and DNA damage checkpoint signaling. Each is linked with ITPKB in more than 10 cancer types. Because this analysis shows association rather than direction, both ITPKB-to-partner and partner-to-ITPKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA integrity checkpoint signaling grouped by ITPKB-low versus ITPKB-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPKB→partner) and Y-score (partner→ITPKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA integrity checkpoint signaling →	+0.082	+1.038	<.001	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of double-strand break repair →	+0.085	+1.314	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	DNA damage checkpoint signaling →	+0.076	+0.986	<.001	<.001	2	10
SKIN	Phosphatidylinositol 3-kinase/protein kinase B signal transduction →	+0.064	+1.619	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Cell cycle checkpoint signaling →	+0.088	+1.038	<.001	.002	3	9
OESOPHAGUS	miRNA processing →	+0.119	+1.360	.001	.008	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,095 associations by consensus.

DNA integrity checkpoint signaling by ITPKB expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →