ITPKB

Across TCGA cell cohorts, ITPKB mutation is significantly associated with the RNA expression of many other genes, with 638 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITPKB-associated genes across cancer lineages are USP17L3, SOWAHB, and ZBTB21. Each is linked with ITPKB in more than 2 cancer types. Because this analysis shows association rather than direction, both ITPKB-to-partner and partner-to-ITPKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L3 grouped by ITPKB-low versus ITPKB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPKB→partner) and Y-score (partner→ITPKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	USP17L3 →	+0.010	+2.922	<.001	.009	3	3
BLOOD_Lymphoma	SOWAHB →	+0.163	+4.129	<.001	.001	3	2
LARGE_INTESTINE	ZBTB21 →	+0.524	+3.386	.003	.001	3	2
LUNG_NSCLC_LUSC	CCL13 →	+0.040	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	MBD3L3 →	+0.020	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	GAGE12J →	+0.266	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 638 associations by consensus.

USP17L3 by ITPKB expression — BLOOD_Leukemia

Explore this box plot interactively →