Across TCGA pan-cancer cohorts, ITPKB-IT1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ITPKB-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ITPKB-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types ITPKB-IT1 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

LUSC, KICH, and COAD are the cancer types where ITPKB-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITPKB-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	−0.268	<.001	8	view →
KICH	All	All	−0.213	<.001	6	view →
COAD	All	III,IV	−0.134	.014	6	view →
BRCA	All	III,IV	−0.166	.001	2	view →
CHOL	Male	All	+0.148	.006	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ITPKB-IT1 RNA expression & survival · all ITPKB-IT1 data types