ITPKA

Across TCGA patient cohorts, ITPKA mutation is significantly associated with the RNA expression of many other genes, with 104 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ITPKA-associated genes across cancer lineages are LINC01758, OR4F21, and RNU6-627P. Each is linked with ITPKA in more than 1 cancer types. Because this analysis shows association rather than direction, both ITPKA-to-partner and partner-to-ITPKA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01758 grouped by ITPKA-low versus ITPKA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPKA→partner) and Y-score (partner→ITPKA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01758 →	+0.181	+3.134	.004	.005	3	2
COAD	OR4F21 →	+0.087	+5.080	<.001	.008	3	1
SKCM	RNU6-627P →	+0.333	+7.816	<.001	.008	3	1
SKCM	RNY4P28 →	+0.597	+7.816	<.001	.008	3	1
SKCM	RNU4-20P →	+0.244	+7.816	<.001	.008	3	1
SKCM	RNU6-768P →	+0.543	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 104 associations by consensus.

LINC01758 by ITPKA expression — UCEC

Explore this box plot interactively →