ITPKA

Across TCGA cell cohorts, ITPKA mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITPKA-associated genes across cancer lineages are PRSS54, C10orf53, and C14orf180. Each is linked with ITPKA in more than 1 cancer types. Because this analysis shows association rather than direction, both ITPKA-to-partner and partner-to-ITPKA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS54 grouped by ITPKA-low versus ITPKA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPKA→partner) and Y-score (partner→ITPKA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRSS54 →	+0.038	+3.345	<.001	.007	3	2
LARGE_INTESTINE	C10orf53 →	+0.012	+3.632	<.001	.003	3	1
LARGE_INTESTINE	C14orf180 →	+0.104	+4.155	.002	.003	3	1
LARGE_INTESTINE	LCE1B →	+0.118	+3.878	.006	.003	3	1
LARGE_INTESTINE	OOSP4A →	+0.137	+4.115	<.001	.001	3	1
BREAST	MYF5 →	+0.023	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PRSS54 by ITPKA expression — LARGE_INTESTINE

Explore this box plot interactively →