ITPK1

Across TCGA pan-cancer cohorts, ITPK1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ITPK1 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ITPK1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITPK1 expression acts as an unfavorable survival marker.

COAD, GBM, and PDAC are the cancer types where ITPK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
GBM	OS	Tertile	All	0.409	0.603	.024	4	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →
LUAD	OS	Tertile	II,III,IV	0.458	0.927	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ITPK1–COAD (DFS)

Open the COAD breakdown →