ITPK1

Across TCGA pan-cancer cohorts, ITPK1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ITPK1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ITPK1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ITPK1 is over-expressed in tumor, although a few such as LUAD and BLCA show the opposite, repressed pattern.

HNSC, LIHC, and LUAD are the cancer types where ITPK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITPK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.173	<.001	12	view →
LIHC	Female	II,III,IV	+1.220	<.001	9	view →
LUAD	Male	All	−0.819	<.001	9	view →
BLCA	Male	III,IV	−1.418	.002	8	view →
STAD	All	II,III,IV	+0.929	<.001	8	view →
READ	All	All	−0.586	.004	6	view →
LUSC	Male	All	−0.584	<.001	5	view →
THCA	All	All	+0.288	.003	5	view →
KIRC	Male	II,III,IV	−0.370	.010	4	view →
KICH	Female	All	+0.665	.004	2	view →
PRAD	All	All	−0.374	<.001	2	view →
UCEC	All	All	−0.364	.049	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ITPK1–HNSC

Open the HNSC breakdown →