ITPK1

Across TCGA patient cohorts, ITPK1 mutation is significantly associated with the RNA expression of many other genes, with 3,256 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITPK1-associated genes across cancer lineages are RNA5SP175, PRAMEF13, and MIR6781. Each is linked with ITPK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITPK1-to-partner and partner-to-ITPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP175 grouped by ITPK1-low versus ITPK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPK1→partner) and Y-score (partner→ITPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP175 →	+0.516	+1.778	.003	.001	3	3
LIHC	PRAMEF13 →	+0.028	+4.720	<.001	.005	3	2
UCEC	MIR6781 →	+0.493	+1.596	<.001	.008	3	2
BRCA	OR10R3P →	+0.091	+5.586	<.001	.001	3	2
BRCA	KRT17P4 →	+0.020	+3.995	.007	.001	3	2
BRCA	LINC01363 →	+0.208	+4.077	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,256 associations by consensus.

RNA5SP175 by ITPK1 expression — UCEC

Explore this box plot interactively →