ITPK1

Across TCGA patient cohorts, ITPK1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITPK1-associated genes across cancer lineages are Notch1, PCNA, and ATM. Each is linked with ITPK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITPK1-to-partner and partner-to-ITPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ITPK1-low versus ITPK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPK1→partner) and Y-score (partner→ITPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.140	+2.000	.011	.010	3	2
UCEC	PCNA →	+0.214	+2.700	.011	.006	3	2
UCEC	ATM →	-0.592	-3.169	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.271	-2.000	.006	.030	3	1
UCEC	JNK_pT183_Y185 →	-0.153	-1.700	.021	.042	3	1
UCEC	JNK2 →	+0.180	+1.584	.020	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Notch1 by ITPK1 expression — UCEC

Explore this box plot interactively →