ITPK1

Across TCGA cell cohorts, ITPK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,000 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ITPK1-associated GO terms across cancer lineages are Inositol trisphosphate metabolic process, Regulation of protein localization to endoplasmic reticulum, and Negative regulation of calcium ion export across plasma membrane. Each is linked with ITPK1 in more than 16 cancer types. Because this analysis shows association rather than direction, both ITPK1-to-partner and partner-to-ITPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Inositol trisphosphate metabolic process grouped by ITPK1-low versus ITPK1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPK1→partner) and Y-score (partner→ITPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Inositol trisphosphate metabolic process →	+0.183	+1.547	.001	<.001	2	17
BLOOD_Lymphoma	Regulation of protein localization to endoplasmic reticulum →	+0.092	+1.127	.004	<.001	3	9
BLOOD_Leukemia	Negative regulation of calcium ion export across plasma membrane →	+0.065	+0.789	<.001	<.001	3	8
SKIN	Multi-pass transmembrane protein insertion into ER membrane →	+0.136	+1.060	<.001	<.001	3	7
KIDNEY	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.104	+1.111	<.001	<.001	3	7
SKIN	Phospholipid biosynthetic process →	+0.036	+0.877	.002	.007	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,000 associations by consensus.

Inositol trisphosphate metabolic process by ITPK1 expression — KIDNEY

Explore this box plot interactively →